Mechanisms of inhibitions of DNA polymerase gamma by nucleotide analogues having anti-HIV activities.

S. Izuta, M. Saneyoshi, T. Sakurai, M. Suzuki, K. Kojima, S. Yoshida

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Inhibition mechanisms of 5'-triphosphates of 3'-azido-3'-deoxythymidine (AZT-TP) and 3'-deoxythymidine (ddTTP) on extensively purified DNA polymerase gamma from bovine testes were examined by analysis of the products synthesized on singly primed M13mp18 single-stranded DNA or synthetic oligonucleotide template-primer in the presence of analogues. The results indicate that AZT-TP inhibits DNA polymerase gamma in competition with dTTP but is not incorporated into DNA, whereas ddTTP is incorporated into DNA and causes chain termination.

本文言語English
ページ(範囲)79-80
ページ数2
ジャーナルNucleic acids symposium series
25
出版ステータスPublished - 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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