Medical history of circulatory diseases and colorectal cancer death in the JACC Study

Yoshiyuki Watanabe, Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Masayo Kojima, Sadao Suzuki, Shinkan Tokudome, Koji Tamakoshi, Hideaki Toyoshima, Miyuki Kawado, Shuji Hashimoto, Norihiko Hayakawa, Kenji Wakai, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo MikamiYutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

研究成果: Article

7 被引用数 (Scopus)

抄録

Background: Host factors expressed by individual past medical history of hypertension, stroke, and myocardial infarction may have a relationship with colorectal cancer. Methods: As part of the Japan Collaborative Cohort Study (JACC Study) for the Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho), we conducted a follow-up study of 110,792 Japanese inhabitants aged 40-79 years to reveal the relationship of past medical history of hypertension, stroke, and myocardial infarction at the baseline in 1988-1990 with colorectal cancer death for about 10 years up to the end of 1999. Results: Past medical history of hypertension associated with an increased risk of female rectal cancer when analyzing all cancer cases with adjustment for age, body mass index, and exercise (hazard ratio [HR1 = 1.97, 95% confidence interval [CI]; 1.13-3.43). Past medical history of myocardial infarction was also an increased risk for female rectal cancer (HR = 3.05, 95% Cl; 1.28-7.28). Females who had a medical history of stroke had increased risk of rectal cancer without statistical significance. Conclusion: There was a positive association of past medical history of hypertension and myocardial infarction and an increased risk of rectal cancer in women.

本文言語English
ページ(範囲)S168-S172
ジャーナルJournal of epidemiology
15
SUPPL. 2
DOI
出版ステータスPublished - 2005

All Science Journal Classification (ASJC) codes

  • Epidemiology

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