Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

A. Nitta, K. Murase, Y. Furukawa, K. Hayashi, T. Hasegawa, T. Nabeshima

研究成果: Article

29 引用 (Scopus)

抄録

Nerve growth factor is required for the survival and maintenance of cholinergic neurons in the central nervous system.9,15 The direct infusion into the rat's septum of an anti-nerve growth factor monoclonal antibody, which inhibits nerve growth factor bioactivity seven times more strongly than a polyclonal antibody, caused very severe damage to the hippocampal cholinergic system. Anti-nerve growth factor polyclonal antibody also neutralized endogenously occurring nerve growth factor. The infusion of anti-nerve growth factor polyclonal antibody produced a dysfunction of memory and decreased choline acetyltransferase activity and acetylcholinesterase staining in the hippocampus. The cholinergic dysfunction and impairment of memory recovered to the normal level two weeks after cessation of the infusion of the anti-nerve growth factor polyclonal antibody. These results suggest that a deficit of nerve growth factor in the adult brain causes neuronal dysfunction.

元の言語English
ページ(範囲)495-499
ページ数5
ジャーナルNeuroscience
57
発行部数3
DOI
出版物ステータスPublished - 12-1993
外部発表Yes

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Nerve Growth Factor
Antibodies
Cholinergic Agents
Cholinergic Neurons
Choline O-Acetyltransferase
Acetylcholinesterase
Hippocampus
Monoclonal Antibodies
Maintenance
Staining and Labeling
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Nitta, A. ; Murase, K. ; Furukawa, Y. ; Hayashi, K. ; Hasegawa, T. ; Nabeshima, T. / Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats. :: Neuroscience. 1993 ; 巻 57, 番号 3. pp. 495-499.
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Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats. / Nitta, A.; Murase, K.; Furukawa, Y.; Hayashi, K.; Hasegawa, T.; Nabeshima, T.

:: Neuroscience, 巻 57, 番号 3, 12.1993, p. 495-499.

研究成果: Article

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T1 - Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

AU - Nitta, A.

AU - Murase, K.

AU - Furukawa, Y.

AU - Hayashi, K.

AU - Hasegawa, T.

AU - Nabeshima, T.

PY - 1993/12

Y1 - 1993/12

N2 - Nerve growth factor is required for the survival and maintenance of cholinergic neurons in the central nervous system.9,15 The direct infusion into the rat's septum of an anti-nerve growth factor monoclonal antibody, which inhibits nerve growth factor bioactivity seven times more strongly than a polyclonal antibody, caused very severe damage to the hippocampal cholinergic system. Anti-nerve growth factor polyclonal antibody also neutralized endogenously occurring nerve growth factor. The infusion of anti-nerve growth factor polyclonal antibody produced a dysfunction of memory and decreased choline acetyltransferase activity and acetylcholinesterase staining in the hippocampus. The cholinergic dysfunction and impairment of memory recovered to the normal level two weeks after cessation of the infusion of the anti-nerve growth factor polyclonal antibody. These results suggest that a deficit of nerve growth factor in the adult brain causes neuronal dysfunction.

AB - Nerve growth factor is required for the survival and maintenance of cholinergic neurons in the central nervous system.9,15 The direct infusion into the rat's septum of an anti-nerve growth factor monoclonal antibody, which inhibits nerve growth factor bioactivity seven times more strongly than a polyclonal antibody, caused very severe damage to the hippocampal cholinergic system. Anti-nerve growth factor polyclonal antibody also neutralized endogenously occurring nerve growth factor. The infusion of anti-nerve growth factor polyclonal antibody produced a dysfunction of memory and decreased choline acetyltransferase activity and acetylcholinesterase staining in the hippocampus. The cholinergic dysfunction and impairment of memory recovered to the normal level two weeks after cessation of the infusion of the anti-nerve growth factor polyclonal antibody. These results suggest that a deficit of nerve growth factor in the adult brain causes neuronal dysfunction.

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