TY - JOUR
T1 - Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females
AU - Kaneko, Satoshi
AU - Tamakoshi, Akiko
AU - Ohno, Yoshiyuki
AU - Mizoue, Tetsuya
AU - Yoshimura, Takesumi
AU - Toyoshima, Hideaki
AU - Mori, Mitsuru
AU - Motohashi, Yutaka
AU - Hisamichi, Shigeru
AU - Nakamura, Yosikazu
AU - Shimamoto, Takashi
AU - Mikami, Haruo
AU - Hashimoto, Shuji
AU - Inaba, Yutaka
AU - Tanaka, Heizo
AU - Hoshiyama, Yoshiharu
AU - Suzuki, Hiroshi
AU - Shimizu, Hiroyuki
AU - Tokudome, Shinkan
AU - Ito, Yoshinori
AU - Koizumi, Akio
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Nakao, Masahiro
AU - Suzuki, Takaichiro
AU - Hashimoto, Tsutomu
AU - Nose, Takayuki
AU - Hayakawa, Norihiko
AU - Fukuda, Katsuhiro
AU - Kitagawa, Tomoyuki
AU - Kuroki, Toshio
AU - Okamoto, Naoyuki
AU - Ishibashi, Teruo
AU - Shio, Hideo
AU - Tajima, Kazuo
N1 - Funding Information:
The present investigators involved in the JACC study and their affiliations are as follows: Yoshiyuki Ohno (the present chairman of the Monbusho ECC), Akiko Tamakoshi (Secretary General of the Monbusho ECC), and Hideaki Toyoshima, Nagoya University Graduate School of Medicine; Dr Mitsuru Mori, Sapporo Medical University School of Medicine; Dr Yutaka Motohashi, Akita University School of Medicine; Dr Shigeru Hisamichi, Tohoku University Graduate School of Medicine; Dr Yosikazu Nakamura, Jichi Medical School; Dr Takashi Shimamoto, Institute of Community Medicine, University of Tsukuba; Dr Haruo Mikami, Chiba Cancer Center; Dr Shuji Hashimoto, School of Health Sciences and Nursing, University of Tokyo; Dr Yutaka Inaba, Juntendo University School of Medicine; Dr Heizo Tanaka, Medical Research Institute, Tokyo Medical and Dental University; Dr Yoshiharu Hoshiyama, Showa University School of Medicine; Dr Hiroshi Suzuki, Niigata University School of Medicine; Dr Hiroyuki Shimizu, Gifu University School of Medicine; Dr Shinkan Tokudome, Nagoya City University Medical School; Dr Yoshinori Ito, Fujita Health University School of Health Sciences; Dr Akio Koizumi, Graduate School of Medicine and Faculty of Medicine, Kyoto University; Dr Takashi Kawamura, Kyoto University Center for Student Health; Dr Yoshiyuki Watanabe, Kyoto Prefectural University of Medicine, Research Institute for Neurological Diseases and Geriatrics; Dr Masahiro Nakao, Kyoto Prefectural University of Medicine; Dr Takai-chiro Suzuki, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases; Dr Tsutomu Hashimoto, Wakayama Medical College; Dr Takayuki Nose, Tottori University Faculty of Medicine; Dr Norihiko Hayakawa, Research Institute for Radiation Biology and Medicine, Hiroshima University; Dr Takesumi Yoshimura, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan; Dr Katsuhiro Fukuda, Kurume University School of Medicine; Dr Tomoyuki Kitaga-wa, National Cancer Institute; Dr Toshio Kuroki, Institute of Molecular Oncology, Showa University; Dr Naoyuki Okamoto, Kanagawa Cancer Center; Dr Teruo Ishibashi, Asama General Hosp ital; Dr Hideo Shio, Shiga Medical Center; and Dr Kazuo Tajima, Aichi Cancer Center Research Institute. This study was supported by Grant-in-Aid for Scientific Research on Priority Areas (C)-2 (12218237), (C)-1 (12218216) from the Ministry of Education, Science, Sports, and Culture of Japan.
PY - 2003/2
Y1 - 2003/2
N2 - Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95% confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.
AB - Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95% confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.
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U2 - 10.1023/A:1022596104796
DO - 10.1023/A:1022596104796
M3 - Article
C2 - 12708725
AN - SCOPUS:0037306289
SN - 0957-5243
VL - 14
SP - 53
EP - 59
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 1
ER -
