Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

Akiyoshi Uezumi, So Ichiro Fukada, Naoki Yamamoto, Shin'Ichi Takeda, Kunihiro Tsuchida

研究成果: Article査読

777 被引用数 (Scopus)

抄録

Ectopic fat deposition in skeletal muscle is closely associated with several disorders, however, the origin of these adipocytes is not clear, nor is the mechanism of their formation. Satellite cells function as adult muscle stem cells but are proposed to possess multipotency. Here, we prospectively identify PDGFRα+ mesenchymal progenitors as being distinct from satellite cells and located in the muscle interstitium. We show that, of the muscle-derived cell populations, only PDGFRα+ cells show efficient adipogenic differentiation both in vitro and in vivo. Reciprocal transplantations between regenerating and degenerating muscles, and co-culture experiments revealed that adipogenesis of PDGFRα+ cells is strongly inhibited by the presence of satellite cell-derived myofibres. These results suggest that PDGFRα+ mesenchymal progenitors are the major contributor to ectopic fat cell formation in skeletal muscle, and emphasize that interaction between muscle cells and PDGFRα+ mesenchymal progenitors, not the fate decision of satellitecells, has a considerable impact on muscle homeostasis.

本文言語English
ページ(範囲)143-152
ページ数10
ジャーナルNature Cell Biology
12
2
DOI
出版ステータスPublished - 02-2010

All Science Journal Classification (ASJC) codes

  • 細胞生物学

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