Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment

Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, Xichen Hu, Feng Wei, Fumimasa Kitamura, Takahiko Akiyama, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Masaaki Iwatsuki, Yuji Miyamoto, Keisuke MatsusakiJuntaro Yamasaki, Osamu Nagano, Hideyuki Saya, Shumei Song, Patrick Tan, Hideo Baba, Jaffer A. Ajani, Takatsugu Ishimoto

研究成果: ジャーナルへの寄稿学術論文査読

8 被引用数 (Scopus)

抄録

Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a comprehensive proteomic analysis are conducted to comprehensively characterize malignant ascites. Here, we find defects in immune effectors along with immunosuppressive cell accumulation in ascites of patients with gastric cancer (GC) and identify five distinct subpopulations of CD45(−)/EpCAM(−) cells. Mesothelial cells with mesenchymal features in CD45(−)/EpCAM(−) cells are the predominant source of chemokines involved in immunosuppressive myeloid cell (IMC) recruitment. Moreover, mesothelial-mesenchymal transition (MMT)-induced mesothelial cells strongly express extracellular matrix (ECM)-related genes, including tenascin-C (TNC), enhancing metastatic colonization. These findings highlight the definite roles of the mesenchymal cell population in the development of a protumorigenic microenvironment to promote peritoneal dissemination.

本文言語英語
論文番号113613
ジャーナルCell Reports
43
1
DOI
出版ステータス出版済み - 23-01-2024

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学一般

フィンガープリント

「Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル