Metabolic considerations in atrial fibrillation ― Mechanistic insights and therapeutic opportunities

Masahide Harada, Jonathan Melka, Yoshihiro Sobue, Stanley Nattel

研究成果: Review article査読

26 被引用数 (Scopus)


Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and is associated with morbidity and mortality. Over the past 2 decades, there have been major advances in understanding AF pathophysiology, but important knowledge gaps, particularly about targetable basic mechanisms, remain. Recent metabolomic and proteomic studies have shown changes in the expression of molecules involved in metabolic pathways in human and experimental AF, indicating a role for metabolic alterations in AF pathophysiology. AF is characterized by irregular high-frequency excitation and contraction that affect atrial energy demands, circulation and oxygen supply, and change the balance between metabolic demand and supply, causing metabolic stress. Here, we review the information available about AF-induced metabolic changes and their pathophysiological contribution. We also discuss the possibilities of developing novel therapeutic strategies that act by modulating cardiac metabolic processes during AF.

ジャーナルCirculation Journal
出版ステータスPublished - 2017

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学


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