Metamorphosis of mesothelial cells with active horizontal motility in tissue culture

Hirotaka Nagai, Shan Hwu Chew, Yasumasa Okazaki, Satomi Funahashi, Takashi Namba, Takuya Kato, Atsushi Enomoto, Li Jiang, Shinya Akatsuka, Shinya Toyokuni

研究成果: ジャーナルへの寄稿学術論文査読

17 被引用数 (Scopus)

抄録

Mesothelial cells, which have diverse roles in physiology and pathology, constitute the mesothelium along with connective tissue and the basement membrane; the mesothelium serves to shield the somatic cavities. After mesothelial injury, mesothelial cells undergo tissue recovery. However, the mechanism of mesothelial regeneration remains poorly understood. In this study, we used confocal time-lapse microscopy to demonstrate that transformed mesothelial cells (MeT5A) and mouse peritoneal mesothelial cells can randomly migrate between cells in cell culture and in ex vivo tissue culture, respectively. Moreover, peritoneal mesothelial cells changed their morphology from a flattened shape to a cuboidal one prior to the migration. Conversely, MDCKII epithelial cells forming tight cell-cell contacts with one another do not alter the arrangement of adjacent cells during movement. Our evidence complements the current hypotheses of mesothelial regeneration and suggests that certain types of differentiated mesothelial cells undergo morphological changes before initiating migration to repair injured sites.

本文言語英語
論文番号1144
ジャーナルScientific reports
3
DOI
出版ステータス出版済み - 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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