MHC class II invariant chain homologues in rainbow trout (Oncorhynchus mykiss)

Johannes Martinus Dijkstra, Ikunari Kiryu, Bernd Köllner, Yasutoshi Yoshiura, Mitsuru Ototake

研究成果: Article査読

28 被引用数 (Scopus)


The MHC class II invariant chain (Ii or CD74) in higher vertebrates is necessary for normal MHC class II loading in endosomal compartments. Detection of an Ii chain in fish would greatly support the idea that MHC class II function in fish and higher vertebrates is similar. Before this study only Ii homologues had been reported in fish that are unlikely to perform true Ii function. In the present study two Ii-like genes, Onmy-Iclp-1 and Onmy-Iclp-2, were detected in rainbow trout. Conservation of elements, particularly in Onmy-Iclp-1, suggests that the encoded proteins may be involved in MHC class II transport and peptide loading as is the Ii protein. The expression pattern of both rainbow trout genes was similar to that of the MHC class II β chain, with strong expression in the lymphoid tissues, gills and intestine. Analysis of separated peripheral blood leucocyte fractions indicated that expression of Onmy-Iclp-1, Onmy-Iclp-2 and the MHC class II β chain were all highest in B lymphocytes. This agrees with the expectation that the functions of the products of the new genes are closely associated with MHC class II. It is interesting why in rainbow trout there are two proteins that may function similar to Ii in higher vertebrates.

ジャーナルFish and Shellfish Immunology
出版ステータスPublished - 08-2003

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

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