MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Yoko Ogawa, Satoru Morikawa, Hideyuki Okano, Yo Mabuchi, Sadafumi Suzuki, Tomonori Yaguchi, Yukio Sato, Shin Mukai, Saori Yaguchi, Takaaki Inaba, Shinichiro Okamoto, Yutaka Kawakami, Kazuo Tsubota, Yumi Matsuzaki, Shigeto Shimmura

研究成果: ジャーナルへの寄稿学術論文査読

33 被引用数 (Scopus)

抄録

Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pathogenesis of fibrosis. Removal of donor BMSCs rescued mice from disease. Freshly isolated PDGFRα+ Sca-1+ BMSCs expressed MHC class II following transplantation and activated host T cells. A decrease in FOXP3+ CD25+ Treg population was observed. T cells proliferated and secreted IL-6 when stimulated with mismatched BMSCs in vitro. Donor T cells were not involved in fibrosis because transplanting T cell-deficient RAG2 knock out mice bone marrow still caused disease. Once initially triggered by mismatched BMSCs, the autoimmune phenotype was not donor BMSC dependent as the phenotype was observed after effector T cells were adoptively transferred into naïve syngeneic mice. Our data suggest that minor antigen mismatched BMSCs trigger systemic fibrosis in this autoimmune scleroderma model.

本文言語英語
論文番号e09394
ジャーナルeLife
5
JANUARY2016
DOI
出版ステータス出版済み - 26-01-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 免疫学および微生物学一般
  • 生化学、遺伝学、分子生物学一般

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