MHC-restricted cell-mediated cytotoxicity in fish

Teruyuki Nakanishi, Uwe Fischer, Johannes M. Dijkstra, Mitsuru Ototake

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Cytotoxic T cells taken from an individual recovering from a viral infection are capable of killing only virally infected cells which share an MHC haplotype with the host (MHC restriction). Very recently extensive allelic polymorphism of MHC class I genes has been demonstrated in both elasmobranchs and teleosts. Accordingly, we should use effector and target cells with the same MHC haplotype to study the MHC-restricted, antigen-specific cytotoxic T cell response in fish. In this symposium our recent studies on polymorphism and function of shark and rainbow trout MHC I genes were first described, followed by MHC-restricted cell-mediated cytotoxicity against virus-infected cell lines using homozygous clonal rainbow trout (C25 clone) sensitized by DNA immunization with IHNV-G or by infection with IHNV and trout cell line (RTG-2) which shares the same MHC I allele with the trout.

本文言語English
ページ(範囲)1143-1146
ページ数4
ジャーナルFisheries Science
68
DOI
出版ステータスPublished - 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • Aquatic Science

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