MHC-restricted cell-mediated cytotoxicity in fish

Teruyuki Nakanishi, Uwe Fischer, Johannes M. Dijkstra, Mitsuru Ototake

研究成果: Article査読

1 被引用数 (Scopus)


Cytotoxic T cells taken from an individual recovering from a viral infection are capable of killing only virally infected cells which share an MHC haplotype with the host (MHC restriction). Very recently extensive allelic polymorphism of MHC class I genes has been demonstrated in both elasmobranchs and teleosts. Accordingly, we should use effector and target cells with the same MHC haplotype to study the MHC-restricted, antigen-specific cytotoxic T cell response in fish. In this symposium our recent studies on polymorphism and function of shark and rainbow trout MHC I genes were first described, followed by MHC-restricted cell-mediated cytotoxicity against virus-infected cell lines using homozygous clonal rainbow trout (C25 clone) sensitized by DNA immunization with IHNV-G or by infection with IHNV and trout cell line (RTG-2) which shares the same MHC I allele with the trout.

ジャーナルFisheries Science
出版ステータスPublished - 2002

All Science Journal Classification (ASJC) codes

  • Aquatic Science

フィンガープリント 「MHC-restricted cell-mediated cytotoxicity in fish」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。