Microglial Activation during Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy

Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

Tauopathy is characterized by the fibrillar tau accumulation in neurons and glial cells. In order to advance our understanding of the causative mechanisms of tauopathy, neuroinflammation, which has been suggested to play important roles in disease progression, will require particular attention. Neuroinflammation is characterized predominantly by microglial activation. At present, it is still under debate whether microglial activation is a cause or a result of neurodegeneration. To search for a temporal relationship between neurodegeneration and neuroinflammation, our group demonstrated that in vivo imaging (e.g., tau-PET, TSPO-PET, and volumetric MRI) of tauopathy mice strongly supports the evidence of microglial activation along with both pathological tau accumulation and brain atrophy. Both in vivo imaging and histochemical analysis confirmed that microglial TSPO accumulation was the late event during the pathogenesis of tauopathy. On the other hand, it is known that purinergic receptor P2Y12 as a marker of homeostatic microglia cells was reduced at an early stage of disease progression. In this review, we will introduce a phenotypic change of microglia in a mouse model of tauopathy and propose novel approaches to the establishment of imaging biomarkers, thereby targeting the early diagnosis of tauopathy.

本文言語英語
ページ(範囲)S353-S359
ジャーナルJournal of Alzheimer's Disease
64
s1
DOI
出版ステータス出版済み - 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 臨床心理学
  • 老年医学
  • 精神医学および精神衛生

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