MicroRNA expression profiling of cerebrospinal fluid/serum exosomes in children with human herpesvirus 6-associated encephalitis/encephalopathy by high-throughput sequencing

Yuka Torii, Jun ichi Kawada, Kazuhiro Horiba, Toshihiko Okumura, Takako Suzuki, Yoshinori Ito

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Primary human herpesvirus 6 (HHV-6) infection is sometimes accompanied by acute encephalopathy with reduced subcortical diffusion (AED) in immunocompetent children. We investigated exosomal microRNA (miRNA) expression profiles in cerebrospinal fluid (CSF) and sera of patients with HHV-6-associated AED (n = 5) and febrile seizure (FS) (n = 5) using high-throughput sequencing. A total of 176 and 663 miRNAs were identified in CSF and serum exosomes, respectively. Comparative analysis determined that some miRNAs (miR-381-3p, miR-155) were exclusively expressed in the CSF exosomes of AED but not of FS patients, suggesting their potential application as novel diagnostic biomarkers for AED.

本文言語英語
ページ(範囲)151-157
ページ数7
ジャーナルJournal of neurovirology
28
1
DOI
出版ステータス出版済み - 02-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 細胞および分子神経科学
  • ウイルス学

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