MicroRNA Profile of Human Small Intestinal Tumors Compared to Colorectal Tumors

Yoshihito Nakagawa, Yukihiro Akao, Hiromi Yamashita, Tomomitsu Tahara, Kohei Funasaka, Mitsuo Nagasaka, Teiji Kuzuya, Ryoji Miyahara, Senju Hashimoto, Tomoyuki Shibata, Yoshiki Hirooka

研究成果: Article査読

抄録

Small intestinal tumors (adenoma and adenocarcinoma, SIT) are rare, and their microRNA (miRNA) expression profiles have not been established. Previously, we reported a relationship between miRNA expression profiles and the development, growth, morphology, and anticancer drug resistance of colorectal tumors. Here, we demonstrate that the miRNA expression profile of SIT is significantly different from those of tumors of the colon. We compared the onco-related miRNA expression profiles of SIT and colorectal tumors and found them to be different from each other. The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. The profiles of SIT and colorectal carcinomas of miR-7, miR-21, and miR-34a were considerably different. Upregulation of miR-31 expression was not found in any SIT cases. Our data suggested that miR-143 and miR-145 might act as anti-oncomirs common to adenocarcinoma of the small intestine, similar to those of colorectal adenoma and other cancers. However, the expression profiles of the other miRNAs of SIT were significantly different from those of colorectal tumors. These findings contribute useful insights into the tumor development and diagnosis of SIT.

本文言語English
論文番号2604
ジャーナルJournal of Clinical Medicine
11
9
DOI
出版ステータスPublished - 01-05-2022

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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