Microtubules to form memory

Fuyuki Mitsuyama, Yoshio Futatsugi, Masato Okuya, Kostadin Karagiozov, Yoko Kato, Tetsuo Kanno, Hirotoshi Sano, Tadashi Koide

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Microtunbule-depolymerizing agents cause amnesia. Some signal translocations to the stimulated postsynaptic membrane are essential for inducing LTP in CA1 neurons like AMPA receptors, CaMKII and mRNA. On the other hand, LTP requires protein synthesis and gene expression. This indicates that signals generated at the synapse might be transmitted to the nucleus. Recently, we have reported that LTP-producing stimulation makes new microtubule track between cell body and the stimulated postsynaptic membrane in CA1 neurons. This newly produced microtubule track only to the stimulated postsynaptic membrane might be the route of these bi-directional transportation of signals during LTP formation. This lead us the hypothesis of the "endless memory amplifying circuit" that means gene expression-promoting molecules are translocated from postsynaptic membrane to the cell body and enter into nucleus and activate transcription factors, and gene products, which will probably promote plasticity, may be re-translocated only to the stimulated postsynaptic membrane along microtubules.

本文言語English
ページ(範囲)227-236
ページ数10
ジャーナルItalian Journal of Anatomy and Embryology
113
4
出版ステータスPublished - 01-10-2008

All Science Journal Classification (ASJC) codes

  • 解剖学
  • 胎生学

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