Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly

Chisato Fujisawa, Hiroyuki Umegaki, Taiki Sugimoto, Satoshi Samizo, Chi Hsien Huang, Haruki Fujisawa, Yoshihisa Sugimura, Masafumi Kuzuya, Kenji Toba, Takashi Sakurai

研究成果: Article査読

抄録

Background: Mild hyponatremia (serum sodium 130–135 mEq/L) is a common electrolyte disorder in the elderly. However, its association with both sarcopenia and cognitive function remains to be clarified. Therefore, here we investigated the association of mild hyponatremia with skeletal muscle mass, physical function, and cognitive function in the elderly. Methods: We enrolled 75 participants with mild hyponatremia and 2907 with normonatremia (serum sodium, 136–145 mEq/L) aged ≥70 years who visited the Memory Disorder Outpatient Center of Japan’s National Center for Geriatrics and Gerontology. Skeletal muscle mass index (SMI), grip strength (GS), walking speed (WS), one-leg standing (OLS) test times, and neuropsychological test scores were determined. Results: One-way analysis of covariance showed that elderly participants with mild hyponatremia had lower SMI (7.1 ± 0.2, 7.2 ± 0.2 kg/m2, p = 0.04), weaker GS (19.1 ± 1.9 vs 21.4 ± 1.8 kg, p = 0.01), slower WS (0.9 ± 0.1 vs 1.1 ± 0.1 m/s, p = 0.001), and higher GDS- 15 score (6.4 ± 0.9 vs 5.2 ± 0.9, p = 0.002) than those with normonatremia. Multiple logistic regression analysis indicated that mild hyponatremia was independently associated with sarcopenia (odds ratio [OR]: 2.2, p = 0.02), slower WS (OR: 5.3, p = 0.04) and shorter OLS time (OR: 2.5, p = 0.02) as well as with severe depressive mood (OR: 2.6 p = 0.006) but not with SMI (OR: 1.6, p = 0.2) or GS (OR: 1.9, p = 0.09). Conclusions: Our results suggest that elderly people with even mild hyponatremia had physical function impairment and depressive mood.

本文言語English
論文番号15
ジャーナルBMC Geriatrics
21
1
DOI
出版ステータスPublished - 12-2021

All Science Journal Classification (ASJC) codes

  • 老年医学

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