抄録
Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.
本文言語 | 英語 |
---|---|
ページ(範囲) | 81-84 |
ページ数 | 4 |
ジャーナル | Journal of Biochemistry |
巻 | 162 |
号 | 2 |
DOI | |
出版ステータス | 出版済み - 01-08-2017 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 医学一般