Mitochondrial distribution and function in herpes simplex virus-infected cells

Takayuki Murata, Fumi Goshima, Tohru Daikoku, Kyoko Inagaki-Ohara, Hiroki Takakuwa, Keisuke Kato, Yukihiro Nishiyama

研究成果: Article

86 引用 (Scopus)

抜粋

In this study, mitochondria migrated to a perinuclear region in the cytoplasm in herpes simplex virus (HSV)-infected cells. HSV infection did not promote the expression of cytochrome c oxidase subunit 2 but did promote that of stress-responsive HSP60, both of which are known to be components of mitochondria. The levels of cellular ATP and lactate and mitochondrial membrane potential were maintained for at least 6 h but decreased at the late stage of infection. It was also found that the UL41 and UL46 gene products, both of which are known to be tegument proteins, accumulated in the perinuclear region. The clustering of mitochondria and the accumulation of tegument proteins were completely blocked by the addition of nocodazole and vinblastine. These results suggest that mitochondria respond to the stimulation of HSV infection, migrating with tegument proteins along microtubules to a site around the nucleus, and maintain function until at least the middle stage of infection.

元の言語English
ページ(範囲)401-406
ページ数6
ジャーナルJournal of General Virology
81
発行部数2
DOI
出版物ステータスPublished - 01-01-2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Virology

フィンガープリント Mitochondrial distribution and function in herpes simplex virus-infected cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Murata, T., Goshima, F., Daikoku, T., Inagaki-Ohara, K., Takakuwa, H., Kato, K., & Nishiyama, Y. (2000). Mitochondrial distribution and function in herpes simplex virus-infected cells. Journal of General Virology, 81(2), 401-406. https://doi.org/10.1099/0022-1317-81-2-401