MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

Toshitaka Nabeshima, Shigeru Yoshida, Hironobu Morinaka, Tsutomu Kameyama, Andrew Thurkauf, Kenner C. Rice, Arthur E. Jacobson, James A. Monn, Arthur K. Cho

研究成果: Article査読

24 被引用数 (Scopus)

抄録

The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

本文言語English
ページ(範囲)321-327
ページ数7
ジャーナルNeuroscience Letters
108
3
DOI
出版ステータスPublished - 22-01-1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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