MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

Toshitaka Nabeshima; Shigeru Yoshida; Hironobu Morinaka; Tsutomu Kameyama; Andrew Thurkauf; Kenner C. Rice; Arthur E. Jacobson; James A. Monn; Arthur K. Cho

doi:10.1016/0304-3940(90)90661-R

MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

Toshitaka Nabeshima
, Shigeru Yoshida
, Hironobu Morinaka
, Tsutomu Kameyama
, Andrew Thurkauf
, Kenner C. Rice
, Arthur E. Jacobson
, James A. Monn
, Arthur K. Cho

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

抄録

The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

本文言語	英語
ページ（範囲）	321-327
ページ数	7
ジャーナル	Neuroscience Letters
巻	108
号	3
DOI	https://doi.org/10.1016/0304-3940(90)90661-R
出版ステータス	出版済み - 22-01-1990
外部発表	はい

All Science Journal Classification (ASJC) codes

神経科学一般

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10.1016/0304-3940(90)90661-R

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title = "MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO",

abstract = "The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.",

author = "Toshitaka Nabeshima and Shigeru Yoshida and Hironobu Morinaka and Tsutomu Kameyama and Andrew Thurkauf and Rice, \{Kenner C.\} and Jacobson, \{Arthur E.\} and Monn, \{James A.\} and Cho, \{Arthur K.\}",

year = "1990",

month = jan,

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doi = "10.1016/0304-3940(90)90661-R",

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TY - JOUR

T1 - MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

AU - Nabeshima, Toshitaka

AU - Yoshida, Shigeru

AU - Morinaka, Hironobu

AU - Kameyama, Tsutomu

AU - Thurkauf, Andrew

AU - Rice, Kenner C.

AU - Jacobson, Arthur E.

AU - Monn, James A.

AU - Cho, Arthur K.

PY - 1990/1/22

Y1 - 1990/1/22

N2 - The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

AB - The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

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AN - SCOPUS:0025105163

SN - 0304-3940

VL - 108

SP - 321

EP - 327

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

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