Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor

Yoshifumi Matsui, Miyako Goto, Mayumi Iwakawa, Takehide Asano, Takashi Kenmochi, Takashi Imai, Takenori Ochiai

研究成果: Article

5 引用 (Scopus)

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We investigated the effects of the farnesyl transferase inhibitor (FTI) manumycin and the MEK inhibitor PD98059 on growth of human pancreatic cancer, with mutant (SUIT2) or wild-type (BxPC-3) K-ras, xenografted into nude mice. Tumor growth was not reduced by either of the agents at a dose of 3 mg/kg without irradiation. Growth of SUIT2 irradiated at 15 Gy or 30 Gy was reduced by manumycin and PD98059: at 15 Gy, tumor volume doubling time (TVDT) increased from 18.6±3.8 to 36.3±14.2 days with PD98059 (p<0.05); at 30 Gy, TVDT increased from 32.8±6.8 to 70.5±10.5 days and 70.7±1.5 days, respectively. Manumycin tended to reduce growth of BxPC-3, but the difference in TVDT was not statistically significant. PD98059 significantly increased the TVDT of BxPC-3 at 30 Gy from 34.4±18 to 62.6±9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer.

元の言語English
ページ(範囲)1525-1528
ページ数4
ジャーナルOncology reports
10
発行部数5
出版物ステータスPublished - 01-09-2003
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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  • これを引用

    Matsui, Y., Goto, M., Iwakawa, M., Asano, T., Kenmochi, T., Imai, T., & Ochiai, T. (2003). Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor. Oncology reports, 10(5), 1525-1528.