Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations

Y. H. Zhang, T. Yoshida, K. Isobe, S. M.J. Rahman, F. Nagase, L. Ding, I. Nakashima

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Glycyrrhizin (GL), a saponin fraction of licorice with defined chemical structure, was shown to display a definite action in vitro augmenting the cell-surface expression of H-2 class I antigens as well as class I gene transcription on various tumour cell lines. The magnitude of augmentation was varied among eight different cell lines tested, but reached more than three times. It was also found that GL enhanced the expression of H-2D(d) antigens in some normal cell populations in vivo. The augmentation of H-2 class I antigens on tumour cell lines in vitro was probably not mediated by the interferon, which might have been produced by the cultured cells. These findings may suggest a new immunopharmacological action of GL.

本文言語English
ページ(範囲)405-410
ページ数6
ジャーナルImmunology
70
3
出版ステータスPublished - 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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