TY - JOUR
T1 - Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate
AU - Panetti, Tracee Scalise
AU - Magnusson, Magnus K.
AU - Peyruchaud, Olivier
AU - Zhang, Qinghong
AU - Cooke, Mary E.
AU - Sakai, Takao
AU - Mosher, Deane F.
PY - 2001/4
Y1 - 2001/4
N2 - Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SPP) are lipid mediators released upon platelet activation. The concentration of LPA in serum is estimated at 1-10 μM whereas the concentration in plasma is considerably less [1]. The SPP concentration in serum is 0.5 μM, approximately two-fold higher than the plasma concentration [1]. The lipids are present during tissue injury and promote cellular processes involved in wound repair [2]. LPA and SPP have multiple effects on cells, many of which are pertinent to wound healing and require that the cells interact in some fashion with components of the extracellular matrix. This review focuses on modulation of cell adhesion, cell migration, collagen gel contraction, and fibronectin matrix assembly by LPA and SPP.
AB - Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SPP) are lipid mediators released upon platelet activation. The concentration of LPA in serum is estimated at 1-10 μM whereas the concentration in plasma is considerably less [1]. The SPP concentration in serum is 0.5 μM, approximately two-fold higher than the plasma concentration [1]. The lipids are present during tissue injury and promote cellular processes involved in wound repair [2]. LPA and SPP have multiple effects on cells, many of which are pertinent to wound healing and require that the cells interact in some fashion with components of the extracellular matrix. This review focuses on modulation of cell adhesion, cell migration, collagen gel contraction, and fibronectin matrix assembly by LPA and SPP.
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U2 - 10.1016/S0090-6980(01)00102-2
DO - 10.1016/S0090-6980(01)00102-2
M3 - Article
C2 - 11324710
AN - SCOPUS:0035002259
SN - 0090-6980
VL - 64
SP - 93
EP - 106
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
IS - 1-4
ER -