Molecular and immunohistochemical detection of rotavirus in urinary sediment cells of children with rotavirus gastroenteritis

T. Yokoyama, N. Sugimoto, K. Taniguchi, S. Komoto, T. Yuno, K. Ohta, H. Hashimoto, A. Seno, A. Ashida, M. Fujieda, S. Nishio, K. Ueno, M. Shimizu, A. Yachie

研究成果: Article査読

3 被引用数 (Scopus)

抄録

This is the first report showing that rotavirus infects the urinary sediment cells in immunocompetent children with rotavirus gastroenteritis. We found that inclusion-bearing cells were frequently detected in the urine samples of patients with rotavirus gastroenteritis. These cells were positive for cytokeratin, which was sometimes coexpressed with rotavirus antigen, in our immunohistochemical analysis. Moreover, in nested RT-PCR experiments, we detected rotavirus double-stranded RNA in some urine samples of patients with rotavirus gastroenteritis. We concluded that rotavirus could lead to infection of the urinary sediment cells concomitantly with rotavirus gastroenteritis.

本文言語English
ページ(範囲)1190-1193
ページ数4
ジャーナルClinical Microbiology and Infection
17
8
DOI
出版ステータスPublished - 08-2011

All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 感染症

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