A cDNA encoding the rat transforming growth factor-β(TGF-β) type II receptor was isolated by hybridization from a rat pituitary gland cDNA library. The rat TGF-β type II receptor comprises 567 amino acid residues with a cysteine-rich extracellular domain, a single transmembrane domain and an intracellular protein kinase domain with predicted serine/threonine specificity. The comparison of the amino acid sequences of the rat and human TGF-β type II receptors indicated that they are highly conserved particularly in the intracellular kinase domain. RNA blot hybridization and reverse-transcription polymerase chain reaction (RT-PCR) analyses showed that rat TGF-β type II receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung.
|ジャーナル||Biochemical and Biophysical Research Communications|
|出版ステータス||Published - 01-05-1993|
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