Molecular characterization of rat transforming growth factor-β type II receptor

Kunihiro Tsuchida, Kathy A. Lewis, Lawrence S. Mathews, Wylie W. Vale

研究成果: Article査読

72 被引用数 (Scopus)

抄録

A cDNA encoding the rat transforming growth factor-β(TGF-β) type II receptor was isolated by hybridization from a rat pituitary gland cDNA library. The rat TGF-β type II receptor comprises 567 amino acid residues with a cysteine-rich extracellular domain, a single transmembrane domain and an intracellular protein kinase domain with predicted serine/threonine specificity. The comparison of the amino acid sequences of the rat and human TGF-β type II receptors indicated that they are highly conserved particularly in the intracellular kinase domain. RNA blot hybridization and reverse-transcription polymerase chain reaction (RT-PCR) analyses showed that rat TGF-β type II receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung.

本文言語English
ページ(範囲)790-795
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
191
3
DOI
出版ステータスPublished - 01-05-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Molecular characterization of rat transforming growth factor-β type II receptor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル