TY - JOUR
T1 - Molecular characterization of rat transforming growth factor-β type II receptor
AU - Tsuchida, Kunihiro
AU - Lewis, Kathy A.
AU - Mathews, Lawrence S.
AU - Vale, Wylie W.
PY - 1993/5/1
Y1 - 1993/5/1
N2 - A cDNA encoding the rat transforming growth factor-β(TGF-β) type II receptor was isolated by hybridization from a rat pituitary gland cDNA library. The rat TGF-β type II receptor comprises 567 amino acid residues with a cysteine-rich extracellular domain, a single transmembrane domain and an intracellular protein kinase domain with predicted serine/threonine specificity. The comparison of the amino acid sequences of the rat and human TGF-β type II receptors indicated that they are highly conserved particularly in the intracellular kinase domain. RNA blot hybridization and reverse-transcription polymerase chain reaction (RT-PCR) analyses showed that rat TGF-β type II receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung.
AB - A cDNA encoding the rat transforming growth factor-β(TGF-β) type II receptor was isolated by hybridization from a rat pituitary gland cDNA library. The rat TGF-β type II receptor comprises 567 amino acid residues with a cysteine-rich extracellular domain, a single transmembrane domain and an intracellular protein kinase domain with predicted serine/threonine specificity. The comparison of the amino acid sequences of the rat and human TGF-β type II receptors indicated that they are highly conserved particularly in the intracellular kinase domain. RNA blot hybridization and reverse-transcription polymerase chain reaction (RT-PCR) analyses showed that rat TGF-β type II receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung.
UR - http://www.scopus.com/inward/record.url?scp=0027257850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027257850&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1993.1286
DO - 10.1006/bbrc.1993.1286
M3 - Article
C2 - 8385453
AN - SCOPUS:0027257850
VL - 191
SP - 790
EP - 795
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -