TY - JOUR
T1 - Molecular epidemiology of KPC-producing Escherichia coli
T2 - Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid
AU - O'Hara, Jessica A.
AU - Hu, Fupin
AU - Ahn, Chulsoo
AU - Nelson, Jeremy
AU - Rivera, Jesabel I.
AU - Pasculle, Anthony W.
AU - Doi, Yohei
PY - 2014/7
Y1 - 2014/7
N2 - Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.
AB - Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.
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U2 - 10.1128/AAC.02182-13
DO - 10.1128/AAC.02182-13
M3 - Article
C2 - 24820082
AN - SCOPUS:84903192771
SN - 0066-4804
VL - 58
SP - 4234
EP - 4237
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -
