抄録
Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder; thus an insight into the cellular actions of Aβ and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Aβ-induced brain dysfunction, especially cholinergic impairment and memory deficits, is summarized. Moreover, proposed mechanisms for Aβ-induced neurotoxicity such as oxidative stress, ion-channel formation, and Aβ-receptor interaction are discussed.
本文言語 | English |
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ページ(範囲) | 125-132 |
ページ数 | 8 |
ジャーナル | Japanese Journal of Psychopharmacology |
巻 | 21 |
号 | 4 |
出版ステータス | Published - 29-12-2001 |
All Science Journal Classification (ASJC) codes
- 医学(全般)