Molecular process in acute liver injury and regeneration induced by carbon tetrachloride

Makoto Taniguchi, Toshiyuki Takeuchi, Ryusuke Nakatsuka, Tatsuo Watanabe, Kenzo Sato

研究成果: ジャーナルへの寄稿学術論文査読

104 被引用数 (Scopus)


Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factors. Down-regulation of liver-specific genes was accomplished through suppression of liver-enriched transcription factors and box A factors found in the catalase gene, and induction of NF-κB, AP-1 and a novel factor denoted as 'cx' in the catalase gene. Expression profiles of these genes were restored to normal levels in the late stage of injury (48h). On the other hand, hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) were induced in the early stage (6h) and 36h, respectively. Interestingly, ERK2 was transiently activated at 3h CCl4-treatment. These observations suggested that hepatotoxin by CCl4-injection concomitantly induces both processes in acute injury and liver regeneration.

ジャーナルLife Sciences
出版ステータス出版済み - 13-08-2004

All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学一般
  • 生化学、遺伝学、分子生物学一般


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