Molecular process in acute liver injury and regeneration induced by carbon tetrachloride

Makoto Taniguchi, Toshiyuki Takeuchi, Ryusuke Nakatsuka, Tatsuo Watanabe, Kenzo Sato

研究成果: Article査読

93 被引用数 (Scopus)

抄録

Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factors. Down-regulation of liver-specific genes was accomplished through suppression of liver-enriched transcription factors and box A factors found in the catalase gene, and induction of NF-κB, AP-1 and a novel factor denoted as 'cx' in the catalase gene. Expression profiles of these genes were restored to normal levels in the late stage of injury (48h). On the other hand, hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) were induced in the early stage (6h) and 36h, respectively. Interestingly, ERK2 was transiently activated at 3h CCl4-treatment. These observations suggested that hepatotoxin by CCl4-injection concomitantly induces both processes in acute injury and liver regeneration.

本文言語English
ページ(範囲)1539-1549
ページ数11
ジャーナルLife Sciences
75
13
DOI
出版ステータスPublished - 13-08-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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