Morphologic effects of artemisinin in Plasmodium falciparum

Yoshimasa Maeno, T. Toyoshima, H. Fujioka, Y. Ito, S. R. Meshnick, A. Benakis, W. K. Milhous, M. Aikawa

研究成果: Article

70 引用 (Scopus)

抄録

Ultrastructural changes induced in Plasmodium falciparum by artemisinin were studied in vitro. Electron microscopic autoradiography was performed on infected erythrocytes that were exposed in vitro to 3H-dihydroartemisinin and 14C-artemisinin. These drugs consistently were located in food vacuoles and mitochondria. Two hours after administration, changes were observed in parasite mitochondria, rough endoplasmic reticulum, and nuclear envelope. At four hours, in addition to the earlier changes, nuclear membranes and, to a lesser extent, some plasma membranes formed myelin figures. In addition, there was a disappearance of ribosomes, and a destruction of food vacuole membranes. These changes may lead to the total disorganization of the parasites. Approximately 30% of the parasites manifested these alterations.

元の言語English
ページ(範囲)485-491
ページ数7
ジャーナルAmerican Journal of Tropical Medicine and Hygiene
49
発行部数4
DOI
出版物ステータスPublished - 01-01-1993

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Plasmodium falciparum
Parasites
dihydroartemisinin
Nuclear Envelope
Vacuoles
Mitochondria
Food
Rough Endoplasmic Reticulum
Myelin Sheath
Autoradiography
Ribosomes
Erythrocytes
Cell Membrane
Electrons
Membranes
Pharmaceutical Preparations
artemisinine
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

これを引用

Maeno, Y., Toyoshima, T., Fujioka, H., Ito, Y., Meshnick, S. R., Benakis, A., ... Aikawa, M. (1993). Morphologic effects of artemisinin in Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene, 49(4), 485-491. https://doi.org/10.4269/ajtmh.1993.49.485
Maeno, Yoshimasa ; Toyoshima, T. ; Fujioka, H. ; Ito, Y. ; Meshnick, S. R. ; Benakis, A. ; Milhous, W. K. ; Aikawa, M. / Morphologic effects of artemisinin in Plasmodium falciparum. :: American Journal of Tropical Medicine and Hygiene. 1993 ; 巻 49, 番号 4. pp. 485-491.
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Maeno, Y, Toyoshima, T, Fujioka, H, Ito, Y, Meshnick, SR, Benakis, A, Milhous, WK & Aikawa, M 1993, 'Morphologic effects of artemisinin in Plasmodium falciparum', American Journal of Tropical Medicine and Hygiene, 巻. 49, 番号 4, pp. 485-491. https://doi.org/10.4269/ajtmh.1993.49.485

Morphologic effects of artemisinin in Plasmodium falciparum. / Maeno, Yoshimasa; Toyoshima, T.; Fujioka, H.; Ito, Y.; Meshnick, S. R.; Benakis, A.; Milhous, W. K.; Aikawa, M.

:: American Journal of Tropical Medicine and Hygiene, 巻 49, 番号 4, 01.01.1993, p. 485-491.

研究成果: Article

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