Morphological change in Pseudomonas aeruginosa following antibiotic treatment of experimental infection in mice and its relation to susceptibility to phagocytosis and to release of endotoxin

Takashi Yokochi, Kayou Narita, Akiko Morikawa, Kazuko Takahashi, Yutaka Kato, Tuyoshi Sugiyama, Naoki Koide, Makoto Kawai, Masako Fukada, Tomoaki Yoshida

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The relationship between morphological changes in Pseudomonas aeruginosa following antibiotic treatment of experimental infection in mice, susceptibility to phagocytosis, and release of endotoxin was studied. The intraperitoneal administration of P. aeruginosa with imipenem or ceftazidime into mice induced morphological changes in the cells 2 h after injection. Round P. aeruginosa cells with imipenem treatment became susceptible to phagocytosis by peritoneal cells, whereas long filamentous cells with ceftazidime treatment were hardly phagocytized by peritoneal cells. The morphological changes also affected the plasma endotoxin level in the circulation.

本文言語English
ページ(範囲)205-206
ページ数2
ジャーナルAntimicrobial agents and chemotherapy
44
1
DOI
出版ステータスPublished - 2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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