mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats

Miyuki Ota, Keiji Mori, Akira Nakashima, Yoko S. Kaneko, Goro Takami, Akira Ota

研究成果: Article

5 引用 (Scopus)

抄録

This study was undertaken to find an answer to the discrepancy between enhanced leptin mRNA expression level in white adipose tissue and its normal serum level in the rats given risperidone of 0.1 mg/kg/day (an equivalent dose to the standard one used for patients) for 21 consecutive days. In the white adipose tissues of rats injected with risperidone, mRNA expression levels of the genes encoding truncated a form of leptin receptor (Ob-Ra) and suppressor of cytokine signaling-3 (SOCS-3) were up-regulated; α1c-adrenergic receptor subtype mRNA expession level was down-regulated. On the contrary, the mRNA expression levels of the genes encoding long form of leptin receptor (Ob-Rb), Ob-Ra, SOCS-3, and neuropeptides known to regulate the appetite were not altered in the hypothalamus, a target site of leptin, obtained from the rats injected with risperidone for 21 consecutive days. These data indicate the importance of the adaptation that occurred in the white adipose tissue of the rats injected with risperidone for semi-chronic duration.

元の言語English
ページ(範囲)299-308
ページ数10
ジャーナルBiogenic Amines
19
発行部数4-6
DOI
出版物ステータスPublished - 01-12-2005

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Risperidone
Leptin
White Adipose Tissue
Leptin Receptors
Messenger RNA
Cytokines
Gene Expression
Appetite
Neuropeptides
Adrenergic Receptors
Hypothalamus
Serum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Pharmacology

これを引用

Ota, Miyuki ; Mori, Keiji ; Nakashima, Akira ; Kaneko, Yoko S. ; Takami, Goro ; Ota, Akira. / mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats. :: Biogenic Amines. 2005 ; 巻 19, 番号 4-6. pp. 299-308.
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mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats. / Ota, Miyuki; Mori, Keiji; Nakashima, Akira; Kaneko, Yoko S.; Takami, Goro; Ota, Akira.

:: Biogenic Amines, 巻 19, 番号 4-6, 01.12.2005, p. 299-308.

研究成果: Article

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