抄録
This study was undertaken to find an answer to the discrepancy between enhanced leptin mRNA expression level in white adipose tissue and its normal serum level in the rats given risperidone of 0.1 mg/kg/day (an equivalent dose to the standard one used for patients) for 21 consecutive days. In the white adipose tissues of rats injected with risperidone, mRNA expression levels of the genes encoding truncated a form of leptin receptor (Ob-Ra) and suppressor of cytokine signaling-3 (SOCS-3) were up-regulated; α1c-adrenergic receptor subtype mRNA expession level was down-regulated. On the contrary, the mRNA expression levels of the genes encoding long form of leptin receptor (Ob-Rb), Ob-Ra, SOCS-3, and neuropeptides known to regulate the appetite were not altered in the hypothalamus, a target site of leptin, obtained from the rats injected with risperidone for 21 consecutive days. These data indicate the importance of the adaptation that occurred in the white adipose tissue of the rats injected with risperidone for semi-chronic duration.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 299-308 |
| ページ数 | 10 |
| ジャーナル | Biogenic Amines |
| 巻 | 19 |
| 発行部数 | 4-6 |
| DOI | |
| 出版物ステータス | Published - 01-12-2005 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Pharmacology
これを引用
}
mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats. / Ota, Miyuki; Mori, Keiji; Nakashima, Akira; Kaneko, Yoko S.; Takami, Goro; Ota, Akira.
：: Biogenic Amines, 巻 19, 番号 4-6, 01.12.2005, p. 299-308.研究成果: Article
TY - JOUR
T1 - mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats
AU - Ota, Miyuki
AU - Mori, Keiji
AU - Nakashima, Akira
AU - Kaneko, Yoko S.
AU - Takami, Goro
AU - Ota, Akira
PY - 2005/12/1
Y1 - 2005/12/1
N2 - This study was undertaken to find an answer to the discrepancy between enhanced leptin mRNA expression level in white adipose tissue and its normal serum level in the rats given risperidone of 0.1 mg/kg/day (an equivalent dose to the standard one used for patients) for 21 consecutive days. In the white adipose tissues of rats injected with risperidone, mRNA expression levels of the genes encoding truncated a form of leptin receptor (Ob-Ra) and suppressor of cytokine signaling-3 (SOCS-3) were up-regulated; α1c-adrenergic receptor subtype mRNA expession level was down-regulated. On the contrary, the mRNA expression levels of the genes encoding long form of leptin receptor (Ob-Rb), Ob-Ra, SOCS-3, and neuropeptides known to regulate the appetite were not altered in the hypothalamus, a target site of leptin, obtained from the rats injected with risperidone for 21 consecutive days. These data indicate the importance of the adaptation that occurred in the white adipose tissue of the rats injected with risperidone for semi-chronic duration.
AB - This study was undertaken to find an answer to the discrepancy between enhanced leptin mRNA expression level in white adipose tissue and its normal serum level in the rats given risperidone of 0.1 mg/kg/day (an equivalent dose to the standard one used for patients) for 21 consecutive days. In the white adipose tissues of rats injected with risperidone, mRNA expression levels of the genes encoding truncated a form of leptin receptor (Ob-Ra) and suppressor of cytokine signaling-3 (SOCS-3) were up-regulated; α1c-adrenergic receptor subtype mRNA expession level was down-regulated. On the contrary, the mRNA expression levels of the genes encoding long form of leptin receptor (Ob-Rb), Ob-Ra, SOCS-3, and neuropeptides known to regulate the appetite were not altered in the hypothalamus, a target site of leptin, obtained from the rats injected with risperidone for 21 consecutive days. These data indicate the importance of the adaptation that occurred in the white adipose tissue of the rats injected with risperidone for semi-chronic duration.
UR - http://www.scopus.com/inward/record.url?scp=29444461196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29444461196&partnerID=8YFLogxK
U2 - 10.1163/156939105774647394
DO - 10.1163/156939105774647394
M3 - Article
AN - SCOPUS:29444461196
VL - 19
SP - 299
EP - 308
JO - Biogenic Amines
JF - Biogenic Amines
SN - 0168-8561
IS - 4-6
ER -