Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model

Hideaki Wakita, Christl Ruetzler, Kachikwu O. Illoh, Yong Chen, Asako Takanohashi, Maria Spatz, John M. Hallenbeck

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Vascular cognitive impairment (VCI) is the second most prevalent type of dementia in the world. The white matter damage that characterizes the common subcortical ischemic form of VCI can be modeled by ligating both common carotid arteries in the Wistar rat to induce protracted cerebral hypoperfusion. In this model, we find that repetitive intranasal administration of recombinant E-selectin to induce mucosal tolerance and to target immunomodulation to activating blood vessels potently suppresses both white matter (and possibly gray matter) damage and markers of vessel activation (tumor necrosis factor and E-selectin); it also preserves behavioral function in T-maze spontaneous alternation, T-maze spatial discrimination memory retention, and object recognition tests. Immunomodulation may be an effective novel strategy to prevent progression of VCI.

本文言語English
ページ(範囲)341-353
ページ数13
ジャーナルJournal of Cerebral Blood Flow and Metabolism
28
2
DOI
出版ステータスPublished - 02-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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