Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Australian Asthma Genetics Consortium (AAGCGC), EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

研究成果: ジャーナルへの寄稿学術論文査読

418 被引用数 (Scopus)

抄録

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

本文言語英語
ページ(範囲)1449-1456
ページ数8
ジャーナルNature Genetics
47
12
DOI
出版ステータス出版済み - 01-12-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学

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