Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4+ and CD8+ T cells to nasal killed-bacillus calmette-guerin in mice

Hiroki Takahashi; Keiko Sasaki; Miyuki Takahashi; Naoko Shigemori; Shyunichi Honda; Hideyuki Arimitsu; Sadayuki Ochi; Naoya Ohara; Takao Tsuji

doi:10.1016/j.vaccine.2006.01.060

Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4⁺ and CD8⁺ T cells to nasal killed-bacillus calmette-guerin in mice

Hiroki Takahashi
, Keiko Sasaki
, Miyuki Takahashi
, Naoko Shigemori
, Shyunichi Honda
, Hideyuki Arimitsu
, Sadayuki Ochi
, Naoya Ohara
, Takao Tsuji

医学部・眼科学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

抄録

On single nasal immunization of mice with killed-bacillus calmette-guerin (BCG) plus a mutant Escherichia coli enterotoxin, delayed-type hypersensitivity was induced and BCG-infection decreased. Spleen cells, particularly CD4 ⁺ T cells among them produced IL-2, IFNγ and TNFα in response to the killed-BCG or purified protein derivatives. CD8⁺ T cells including cytotoxic T lymphocytes produced IFNγ and TNFα. However, both types of T cells reacted a little to Ag85B. The mutant induces cellular immunity to nasal killed-BCG vaccine and decreases BCG-infection. CD4⁺ and CD8⁺ T cells produce cytokines effective for tuberculosis. Although killed-BCG loses some antigens like Ag85B, nasal killed-BCG plus the mutant is useful for tuberculosis.

本文言語	英語
ページ（範囲）	3591-3598
ページ数	8
ジャーナル	Vaccine
巻	24
号	17
DOI	https://doi.org/10.1016/j.vaccine.2006.01.060
出版ステータス	出版済み - 24-04-2006

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All Science Journal Classification (ASJC) codes

分子医療
免疫学および微生物学一般
獣医学一般
公衆衛生学、環境および労働衛生
感染症

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10.1016/j.vaccine.2006.01.060

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引用スタイル

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title = "Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4+ and CD8+ T cells to nasal killed-bacillus calmette-guerin in mice",

abstract = "On single nasal immunization of mice with killed-bacillus calmette-guerin (BCG) plus a mutant Escherichia coli enterotoxin, delayed-type hypersensitivity was induced and BCG-infection decreased. Spleen cells, particularly CD4 + T cells among them produced IL-2, IFNγ and TNFα in response to the killed-BCG or purified protein derivatives. CD8+ T cells including cytotoxic T lymphocytes produced IFNγ and TNFα. However, both types of T cells reacted a little to Ag85B. The mutant induces cellular immunity to nasal killed-BCG vaccine and decreases BCG-infection. CD4+ and CD8+ T cells produce cytokines effective for tuberculosis. Although killed-BCG loses some antigens like Ag85B, nasal killed-BCG plus the mutant is useful for tuberculosis.",

keywords = "Heat-labile enterotoxin, Killed-BCG, Mucosal adjuvant, Mutant",

author = "Hiroki Takahashi and Keiko Sasaki and Miyuki Takahashi and Naoko Shigemori and Shyunichi Honda and Hideyuki Arimitsu and Sadayuki Ochi and Naoya Ohara and Takao Tsuji",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, and for the Open Research Center's Project of Fujita Health University from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2006",

month = apr,

day = "24",

doi = "10.1016/j.vaccine.2006.01.060",

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AU - Takahashi, Hiroki

AU - Sasaki, Keiko

AU - Takahashi, Miyuki

AU - Shigemori, Naoko

AU - Honda, Shyunichi

AU - Arimitsu, Hideyuki

AU - Ochi, Sadayuki

AU - Ohara, Naoya

AU - Tsuji, Takao

N1 - Funding Information: This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, and for the Open Research Center's Project of Fujita Health University from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2006/4/24

Y1 - 2006/4/24

N2 - On single nasal immunization of mice with killed-bacillus calmette-guerin (BCG) plus a mutant Escherichia coli enterotoxin, delayed-type hypersensitivity was induced and BCG-infection decreased. Spleen cells, particularly CD4 + T cells among them produced IL-2, IFNγ and TNFα in response to the killed-BCG or purified protein derivatives. CD8+ T cells including cytotoxic T lymphocytes produced IFNγ and TNFα. However, both types of T cells reacted a little to Ag85B. The mutant induces cellular immunity to nasal killed-BCG vaccine and decreases BCG-infection. CD4+ and CD8+ T cells produce cytokines effective for tuberculosis. Although killed-BCG loses some antigens like Ag85B, nasal killed-BCG plus the mutant is useful for tuberculosis.

AB - On single nasal immunization of mice with killed-bacillus calmette-guerin (BCG) plus a mutant Escherichia coli enterotoxin, delayed-type hypersensitivity was induced and BCG-infection decreased. Spleen cells, particularly CD4 + T cells among them produced IL-2, IFNγ and TNFα in response to the killed-BCG or purified protein derivatives. CD8+ T cells including cytotoxic T lymphocytes produced IFNγ and TNFα. However, both types of T cells reacted a little to Ag85B. The mutant induces cellular immunity to nasal killed-BCG vaccine and decreases BCG-infection. CD4+ and CD8+ T cells produce cytokines effective for tuberculosis. Although killed-BCG loses some antigens like Ag85B, nasal killed-BCG plus the mutant is useful for tuberculosis.

KW - Heat-labile enterotoxin

KW - Killed-BCG

KW - Mucosal adjuvant

KW - Mutant

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DO - 10.1016/j.vaccine.2006.01.060

M3 - Article

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VL - 24

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