Mutually repulsive EphA7–EfnA5 organize region-to-region corticopontine projection by inhibiting collateral extension

Tokuichi Iguchi, Yuichiro Oka, Misato Yasumura, Minoru Omi, Kazuki Kuroda, Hideshi Yagi, Min Jue Xie, Manabu Taniguchi, Martin Bastmeyer, Makoto Sato

研究成果: ジャーナルへの寄稿学術論文査読

4 被引用数 (Scopus)

抄録

Coordination of skilled movements and motor planning relies on the formation of regionally restricted brain circuits that connect cortex with subcortical areas during embryonic development. Layer 5 neurons that are distributed across most cortical areas innervate the pontine nuclei (basilar pons) by protrusion and extension of collateral branches interstitially along their corticospinal extending axons. Pons-derived chemotropic cues are known to attract extending axons, but molecules that regulate collateral extension to create regionally segregated targeting patterns have not been identified. Here, we discovered that EphA7 and EfnA5 are expressed in the cortex and the basilar pons in a region-specific and mutually exclusive manner, and that their repulsive activities are essential for segregating collateral extensions from corticospinal axonal tracts in mice. Specifically, EphA7 and EfnA5 forward and reverse inhibitory signals direct collateral extension such that EphA7-positive frontal and occipital cortical areas extend their axon collaterals into the EfnA5-negative rostral part of the basilar pons, whereas EfnA5-positive parietal cortical areas extend their collaterals into the EphA7-negative caudal part of the basilar pons. Together, our results provide a molecular basis that explains how the corticopontine projection connects multimodal cortical outputs to their subcortical targets.

本文言語英語
ページ(範囲)4795-4808
ページ数14
ジャーナルJournal of Neuroscience
41
22
DOI
出版ステータス出版済み - 02-06-2021

All Science Journal Classification (ASJC) codes

  • 神経科学一般

フィンガープリント

「Mutually repulsive EphA7–EfnA5 organize region-to-region corticopontine projection by inhibiting collateral extension」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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