TY - JOUR
T1 - Myelin formation in myelin-deficient rat spinal cord following transplantation of normal fetal spinal cord
AU - Rosenbluth, J.
AU - Hasegawa, M.
AU - Schiff, R.
N1 - Funding Information:
Supported by grants from the NIH (NS 07495) and National Multiple Sclerosis Society (RG 1579). The authors are indebted to Ron Morella for expert technical assistance. An abstract of this study appears in ref. 7.
PY - 1989/2/13
Y1 - 1989/2/13
N2 - Previous studies of the myelin-deficient rat spinal cord have suggested that astrocytes may play a role in preventing the formation of myelin in this mutant, or causing its breakdown. Comparison of mutant and normal littermate spinal cords shows a marked hypertrophy of astrocytes in the mutant in both gray matter and fiber tract regions. Nevertheless, when normal fetal spinal cord fragments are transplanted into mutant host spinal cord, clusters of normal-looking myelin sheaths develop with no sign of attack by host astrocytes.
AB - Previous studies of the myelin-deficient rat spinal cord have suggested that astrocytes may play a role in preventing the formation of myelin in this mutant, or causing its breakdown. Comparison of mutant and normal littermate spinal cords shows a marked hypertrophy of astrocytes in the mutant in both gray matter and fiber tract regions. Nevertheless, when normal fetal spinal cord fragments are transplanted into mutant host spinal cord, clusters of normal-looking myelin sheaths develop with no sign of attack by host astrocytes.
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U2 - 10.1016/0304-3940(89)90135-3
DO - 10.1016/0304-3940(89)90135-3
M3 - Article
C2 - 2919007
AN - SCOPUS:0024570219
SN - 0304-3940
VL - 97
SP - 35
EP - 40
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -