Myosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells

Naoyuki Inagaki, Miwako Nishizawa, Masaaki Ito, Masaki Fujioka, Takeshi Nakano, Shiho Tsujino, Kaori Matsuzawa, Kazushi Kimura, Kozo Kaibuchi, Masaki Inagaki

研究成果: ジャーナルへの寄稿学術論文査読

28 被引用数 (Scopus)

抄録

We examined the intracellular localization of the myosin binding subunit (MBS) of smooth muscle myosin phosphatase. In MDCK cells in a confluent monolayer of polarized epithelial sheet, MBS was concentrated to the cell-cell adhesion sites. Double-immunofluorescence analysis with anti-MBS and anti-β-catenin antibodies showed that MBS was mainly localized at the adherens junction. Furthermore, MBS was translocated reversibly between the cytosol and the cell-cell adhesion sites during the formation and disappearance of cell-cell contacts. These data suggest that MBS may play an important role in the regulation of the cell-cell adhesion.

本文言語英語
ページ(範囲)552-556
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
230
3
DOI
出版ステータス出版済み - 23-01-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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