TY - JOUR
T1 - National survey of de novo malignancy after solid organ transplantation in Japan
AU - Miyazaki, Takuro
AU - Sato, Shuntaro
AU - Kondo, Takashi
AU - Kusaka, Mamoru
AU - Gotoh, Mitsukazu
AU - Saiki, Yoshikatsu
AU - Ono, Minoru
AU - Kokudo, Norihiro
AU - Enosawa, Shin
AU - Satoh, Shigeru
AU - Soeda, Etsuko
AU - Furukawa, Hiroyuki
AU - Kobayashi, Eiji
AU - Nagayasu, Takeshi
N1 - Funding Information:
The authors would like to thank the members of the academic committee of the Japanese Society for Transplantation and the medical doctors who cooperated with this survey.
Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018.
PY - 2018/1/29
Y1 - 2018/1/29
N2 - Purpose In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results Nine thousand two hundred ten solid organ transplants (kidney, 49.9%; liver, 45.9%; heart, 0.9%; lung, 1.2%; pancreas, 1.9%; small intestine, 0.2%) were performed. Four hundred seventy-nine (5.2%) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8%), liver (n = 186, 38.8%), heart (n = 5, 0.1%), lung (n = 18, 3.8%), pancreas (n = 9, 1.9%), and small intestine (n = 1, 0.02%). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.
AB - Purpose In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results Nine thousand two hundred ten solid organ transplants (kidney, 49.9%; liver, 45.9%; heart, 0.9%; lung, 1.2%; pancreas, 1.9%; small intestine, 0.2%) were performed. Four hundred seventy-nine (5.2%) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8%), liver (n = 186, 38.8%), heart (n = 5, 0.1%), lung (n = 18, 3.8%), pancreas (n = 9, 1.9%), and small intestine (n = 1, 0.02%). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.
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U2 - 10.1007/s00595-018-1628-9
DO - 10.1007/s00595-018-1628-9
M3 - Article
C2 - 29380136
AN - SCOPUS:85041102096
SN - 0941-1291
VL - 48
SP - 618
EP - 624
JO - Surgery Today
JF - Surgery Today
IS - 6
ER -