Native-lung complications following single-lung transplantation for interstitial lung disease: an in-depth analysis

Toshikazu Watanabe, Takashi Hirama, Ken Onodera, Hirotsugu Notsuda, Hisashi Oishi, Hiromichi Niikawa, Kazuyoshi Imaizumi, Yoshinori Okada

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Background: Interstitial lung disease (ILD) represents a heterogeneous group of lung disorders characterized by fibrotic lung tissue changes. In regions with severe donor shortages, single-lung transplantation (SLTx) is often preferred over bilateral lung transplantation for advanced ILD. However, temporal changes and complications in the retained native lung remain poorly understood. Methods: A retrospective analysis of 149 recipients who had undergone SLTx was conducted, including 34 ILD SLTx recipients. Native-lung volume, radiological alterations, and perfusion were assessed at distinct post-SLTx time points. Statistical analyses compared ILD and non-ILD SLTx groups. Results: Our study revealed a progressive reduction in native-lung volume over time, accompanied by radiographic deterioration and declining perfusion. Complications in the retained native lung were observed, such as pneumothorax (29.4%), pulmonary aspergillosis (11.8%), and acute exacerbation (8.9%). Long-term survival rates were similar between ILD and non-ILD SLTx recipients. Conclusions: This study illuminates the unique challenges and complications with respect to the native lung following SLTx for ILD. Ongoing monitoring and tailored management are essential. Despite limitations, this research contributes to our understanding of the temporal progression of native-lung complications post-SLTx for ILD, underscoring the need for further investigation.

本文言語英語
論文番号202
ジャーナルBMC pulmonary medicine
24
1
DOI
出版ステータス出版済み - 12-2024

All Science Journal Classification (ASJC) codes

  • 呼吸器内科

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