Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats

Yijin Yan, Tomoko Mizuno, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Article

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Nefiracetam has been reported to increase intracellular cyclic AMP levels and enhance calcium channel current. Since the cAMP cascade is involved in the development of drug dependence, we investigated whether nefiracetam attenuates the methamphetamine (MAP)-induced discriminative responses in rats. Nefiracetam (50 mg/kg) inhibited MAP-induced discriminative responses. Furthermore, rolipram, raclopride, and L-745870, all of which can enhance cAMP activity, disrupted MAP-paired lever press of rats. Nifedipine and neomycin, which are blockers of voltage-sensitive calcium channels (VSCCs), decreased MAP-induced discriminative responses. However, pretreatment of these VSCC blockers failed to affect the inhibitory effects of nefiracetem on MAP-induced discriminative responses. Our findings suggested that nefiracetam inhibits MAP-induced discriminative responses, which may be at least partly associated with the changes in intracellular cAMP levels.

元の言語English
ページ(範囲)274-278
ページ数5
ジャーナルAnnals of the New York Academy of Sciences
1025
DOI
出版物ステータスPublished - 01-01-2004
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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