Nerve Growth Factor Content of Rat Brain Increases Following Basal-Forebrain Lesions Induced by Ibotenic Acid but Not by Electrolysis

Yoshiko Furukawa, Kyozo Hayashi, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

5 被引用数 (Scopus)

抄録

We attempted to measure the change in the nerve growth factor (NGF) content in the hippocampus and parietal cortex following basal-forebrain lesions induced by ibotenic acid and electrolysis. The NGF content of the parietal cortex and hippocampus increased transiently on days 3 to 7, and then returned to the control level on day 14 after the lesion of the basal forebrain induced by ibotenic acid. Ibotenic acid decreased both the choline acetyltransferase (ChAT) activity in the parietal cortex and the dopamine content in the striatum. Electrolytic lesions of the basal forebrain decreased the dopamine content in the striatum, but did not affect the NGF content and ChAT activity in any of the brain regions examined. These results suggest that the mechanism of NGF synthesis is related to cholinergic, but not to dopaminergic, neurons in the basal forebrain.

本文言語英語
ページ(範囲)34-38
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
17
1
DOI
出版ステータス出版済み - 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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