抄録
Neural stem cells are multipotent progenitor cells that show self-renewal activity. In this study, we assessed the use of neural stem cells for ameliorating ischemia-reperfusion injury of the gerbil cochlea. Neural stem cells were injected into one inner ear through the round window I day after ischemic insult. Immunostaining for nestin showed that the distribution of neural stem cells was concentrated within the organ of Corti. Seven days after ischemia, the injury-induced auditory brainstem response threshold shift and progressive inner hair cell damage were markedly less on the neural stem cell-transplanted side. These results suggest that the transplantation of neural stem cells is therapeutically useful for preventing damage to hair cells that occurs after transient ischemia of the cochlea.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1545-1549 |
ページ数 | 5 |
ジャーナル | Neuroreport |
巻 | 16 |
号 | 14 |
出版ステータス | 出版済み - 28-09-2005 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 神経科学一般