Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia

Nobuhiro Hakuba, Ryuji Hata, Isamu Morizane, Gu Feng, Yoshitaka Shimizu, Kensuke Fujita, Tadashi Yoshida, Masahiro Sakanaka, Kiyofumi Gyo

研究成果: ジャーナルへの寄稿学術論文査読

39 被引用数 (Scopus)

抄録

Neural stem cells are multipotent progenitor cells that show self-renewal activity. In this study, we assessed the use of neural stem cells for ameliorating ischemia-reperfusion injury of the gerbil cochlea. Neural stem cells were injected into one inner ear through the round window I day after ischemic insult. Immunostaining for nestin showed that the distribution of neural stem cells was concentrated within the organ of Corti. Seven days after ischemia, the injury-induced auditory brainstem response threshold shift and progressive inner hair cell damage were markedly less on the neural stem cell-transplanted side. These results suggest that the transplantation of neural stem cells is therapeutically useful for preventing damage to hair cells that occurs after transient ischemia of the cochlea.

本文言語英語
ページ(範囲)1545-1549
ページ数5
ジャーナルNeuroreport
16
14
出版ステータス出版済み - 28-09-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般

フィンガープリント

「Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル