Neuroblastoma Growth Factors Derived from Neurofibroma (NF1): Participation of Uridine in a Neuroblastoma Growth

Taeko Hotta, Kiyofumi Asai, Naohito Takeda, Akira Tatematsu, Keiko Nakanishi, Yaman Z. Eksioglu, Ichiro Isobe, Taiji Kato

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Abstract: Human glioma cell extracts were found to elicit a marked growth‐promoting activity on human neuroblastoma cells. This activity was also detected in the extracts of neurofibroma type 1 (NF1; von Recklinghausen neurofibromatosis) comprising aberrant Schwann cell growth. The purified substance from the NF1 extracts by HPLC on ODS columns was identical to a pyrimidine nucleoside, uridine, the chemical structure of which was identified by gas chromatography‐mass spectrometry. The authentic uridine showed a strong growth‐promoting activity on human neuroblastoma cells. Other purine or pyrimidine nucleotides, their derivatives, and ribose sources for their syntheses were employed to test the activity; a purine nucleoside, adenosine, showed a stronger activity than uridine. The current study raises the possibility that human neuroblastoma cells may be affected by dysfunctions of the de novo pathway of both purine and pyrimidine nucleotide biosyntheses.

本文言語English
ページ(範囲)312-319
ページ数8
ジャーナルJournal of neurochemistry
60
1
DOI
出版ステータスPublished - 01-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞および分子神経科学

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