Neuroblastoma in a transgenic mouse carrying a metallothionein/ret fusion gene

T. Iwamoto, M. Taniguchi, W. Wajjwalku, I. Nakashima, M. Takahashi

研究成果: Article

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We have recently succeeded in producing transgenic mice carrying a hybrid gene consisting of mouse metallothionein promoter-enhancer and the ret oncogene (MT/ret). (Iwamoto et al., 1991b). A retroperitoneal tumour developed in one of 17 MT/ret transgenic founder mice. Histological analysis revealed that the tumour consisted of undifferentiated neuroblasts and differentiated ganglion cells, the latter of which were strongly positive for neuron specific enolase. Expression of the ret transgene was observed at high levels in RNA from the tumour, but not in those of other normal tissues. In addition, a 100kDa ret protein was detected in the cell lysate of the tumour. Taken together with our previous data, these results suggest a possible role for the ret oncogene in the proliferation of neural crest cells.

元の言語English
ページ(範囲)504-507
ページ数4
ジャーナルBritish Journal of Cancer
67
発行部数3
DOI
出版物ステータスPublished - 03-1993
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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