TY - JOUR
T1 - Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-d-aspartate-induced aversive behavior
AU - Maeda, Yohko
AU - Yamada, Kiyofumi
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
N1 - Funding Information:
The authors are grateful to Drs. Masaomi Iyo and Susumu Fukui for their helpful advice on preparation of the manuscript. This study was supported, in part, by grants from the Ministry of Education, Science and Culture, Japan (Nos. 03304036 and 00092093), and by the Sandoz Foundation for Gerontological Research. We are grateful to Sandoz Ltd. for their supply of salmon calcitonin.
PY - 1995/3/6
Y1 - 1995/3/6
N2 - To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.
AB - To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.
KW - 5-HT receptor
KW - Aversive behavior
KW - Calcitonin
KW - GABA receptor
KW - NMDA (N-methyl-d-aspartate)
KW - β-Adrenoceptor
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U2 - 10.1016/0014-2999(94)00764-X
DO - 10.1016/0014-2999(94)00764-X
M3 - Article
C2 - 7796851
AN - SCOPUS:0028930452
SN - 0014-2999
VL - 275
SP - 163
EP - 170
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -