Neuropharmacological effects of sigma receptor ligands: Anxiolytic, anti-amnesic and neuroprotective effects

M. Amano, K. Yamada, K. Matsuno, T. Nabeshima

研究成果: Review article査読

7 被引用数 (Scopus)

抄録

There is evidence for the existence of two classes of sigma binding sites, termed 'site 1' and 'site 2', that are distinct from opioid and PCP receptors. Sigma receptor ligands may be useful in the treatment of schizophrenia, since they improve not only positive but also negative symptoms with little extrapyramidal side effects in animal models. In addition, recent experiments have demonstrated that sigma receptor ligands attenuate the motor suppression and colonic motor disturbances seen under menially stressful situations, stimulate the central cholinergic function thereby ameliorating impairment of learning and memory, and protect cerebral neurons against cerebral ischemic insult. The present review describes the neuropharmacological effects of sigma receptor ligands, especially anxiolytic (anti-stress) effects, ameliorating effects on impairment of learning and memory, and neuroprotective effects.

本文言語English
ページ(範囲)73-84
ページ数12
ジャーナルJapanese Journal of Psychopharmacology
16
3
出版ステータスPublished - 11-09-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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