Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs

Eun Joo Shin, Jae Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau Shyong Hong, Toshitaka Nabeshima, Hyoung Chun Kim

研究成果: Review article

26 引用 (Scopus)

抜粋

Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

元の言語English
ページ(範囲)137-148
ページ数12
ジャーナルJournal of Pharmacological Sciences
116
発行部数2
DOI
出版物ステータスPublished - 24-06-2011
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Shin, E. J., Bach, J. H., Lee, S. Y., Kim, J. M., Lee, J., Hong, J. S., Nabeshima, T., & Kim, H. C. (2011). Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. Journal of Pharmacological Sciences, 116(2), 137-148. https://doi.org/10.1254/jphs.11R02CR