TY - JOUR
T1 - Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs
AU - Shin, Eun Joo
AU - Bach, Jae Hyung
AU - Lee, Sung Youl
AU - Kim, Jeong Min
AU - Lee, Jinhwa
AU - Hong, Jau Shyong
AU - Nabeshima, Toshitaka
AU - Kim, Hyoung Chun
PY - 2011
Y1 - 2011
N2 - Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.
AB - Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.
UR - http://www.scopus.com/inward/record.url?scp=79959347631&partnerID=8YFLogxK
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U2 - 10.1254/jphs.11R02CR
DO - 10.1254/jphs.11R02CR
M3 - Review article
C2 - 21606622
AN - SCOPUS:79959347631
SN - 1347-8613
VL - 116
SP - 137
EP - 148
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 2
ER -