TY - JOUR
T1 - Neutrophil priming as a risk factor for surgical site infection in patients with colon cancer treated by laparoscopic surgery
AU - Toiyama, Yuji
AU - Okugawa, Yoshinaga
AU - Shimura, Tadanobu
AU - Ide, Shozo
AU - Yasuda, Hiromi
AU - Fujikawa, Hiroyuki
AU - Okita, Yoshiki
AU - Yokoe, Takeshi
AU - Hiro, Junichiro
AU - Ohi, Masaki
AU - Kusunoki, Masato
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/1/6
Y1 - 2020/1/6
N2 - Background: The purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically. Methods: In total, 135 colon cancer patients (stage I-III) undergoing curative laparoscopic surgery between January 2004 and December 2013 were enrolled in this study. We collected data on clinicopathological factors, laboratory data on pre and postoperative day 3 (POD3) and tumor markers levels to assess the relation to surgical site infection (SSI) including with anastomotic leakage (AL). Results: SSI and AL occurred in 16 cases (5.6%) and 4 cases (3%), respectively. SSI and AL were not association with clinicopathological factors. Within laboratory data and tumor markers preoperatively, high neutrophil counts were significantly associated with SSI (P < 0.05) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.656 and 0.854, respectively. In addition, high neutrophil counts on POD3 also were significantly associated with SSI (P < 0.01) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.747 and 0.832, respectively. Conclusion: Neutrophil count on pre and POD3 are potentially valuable indicators of SSI including with AL in colon cancer patients undergoing curative surgery laparoscopically.
AB - Background: The purpose of this study is to identify perioperative marker predicting postoperative surgical site infection (SSI) including with anastomotic leakage (AL) in curative colon cancer patients, laparoscopically. Methods: In total, 135 colon cancer patients (stage I-III) undergoing curative laparoscopic surgery between January 2004 and December 2013 were enrolled in this study. We collected data on clinicopathological factors, laboratory data on pre and postoperative day 3 (POD3) and tumor markers levels to assess the relation to surgical site infection (SSI) including with anastomotic leakage (AL). Results: SSI and AL occurred in 16 cases (5.6%) and 4 cases (3%), respectively. SSI and AL were not association with clinicopathological factors. Within laboratory data and tumor markers preoperatively, high neutrophil counts were significantly associated with SSI (P < 0.05) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.656 and 0.854, respectively. In addition, high neutrophil counts on POD3 also were significantly associated with SSI (P < 0.01) and AL (P < 0.01), respectively. Area under curves (AUC) of SSI and AL were 0.747 and 0.832, respectively. Conclusion: Neutrophil count on pre and POD3 are potentially valuable indicators of SSI including with AL in colon cancer patients undergoing curative surgery laparoscopically.
KW - Anastomotic leakage
KW - Colon Cancer
KW - Neutrophil
KW - Surgical site infection
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U2 - 10.1186/s12893-019-0674-6
DO - 10.1186/s12893-019-0674-6
M3 - Article
C2 - 31906993
AN - SCOPUS:85077550035
SN - 1471-2482
VL - 20
JO - BMC Surgery
JF - BMC Surgery
IS - 1
M1 - 5
ER -
