New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima; Atsushi Takahashi; Ikuyo Kou; Cristina Rodriguez-Fontenla; Juan J. Gomez-Reino; Tatsuya Furuichi; Jin Dai; Akihiro Sudo; Atsumasa Uchida; Naoshi Fukui; Michiaki Kubo; Naoyuki Kamatani; Tatsuhiko Tsunoda; Konstantinos N. Malizos; Aspasia Tsezou; Antonio Gonzalez; Yusuke Nakamura; Shiro Ikegawa

doi:10.1371/journal.pone.0009723

New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima, Atsushi Takahashi, Ikuyo Kou, Cristina Rodriguez-Fontenla, Juan J. Gomez-Reino, Tatsuya Furuichi, Jin Dai, Akihiro Sudo, Atsumasa Uchida, Naoshi Fukui, Michiaki Kubo, Naoyuki Kamatani, Tatsuhiko Tsunoda, Konstantinos N. Malizos, Aspasia Tsezou, Antonio Gonzalez, Yusuke Nakamura, Shiro Ikegawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

94 被引用数 (Scopus)

抄録

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10^-8 for rs7775228 and 6.73×10^-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

本文言語	英語
論文番号	e9723
ジャーナル	PloS one
巻	5
号	3
DOI	https://doi.org/10.1371/journal.pone.0009723
出版ステータス	出版済み - 2010
外部発表	はい

All Science Journal Classification (ASJC) codes

一般

文献へのアクセス

10.1371/journal.pone.0009723

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引用スタイル

Nakajima, M., Takahashi, A., Kou, I., Rodriguez-Fontenla, C., Gomez-Reino, J. J., Furuichi, T., Dai, J., Sudo, A., Uchida, A., Fukui, N., Kubo, M., Kamatani, N., Tsunoda, T., Malizos, K. N., Tsezou, A., Gonzalez, A., Nakamura, Y., & Ikegawa, S. (2010). New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. PloS one, 5(3), 記事 e9723. https://doi.org/10.1371/journal.pone.0009723

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title = "New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study",

abstract = "Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.",

author = "Masahiro Nakajima and Atsushi Takahashi and Ikuyo Kou and Cristina Rodriguez-Fontenla and Gomez-Reino, {Juan J.} and Tatsuya Furuichi and Jin Dai and Akihiro Sudo and Atsumasa Uchida and Naoshi Fukui and Michiaki Kubo and Naoyuki Kamatani and Tatsuhiko Tsunoda and Malizos, {Konstantinos N.} and Aspasia Tsezou and Antonio Gonzalez and Yusuke Nakamura and Shiro Ikegawa",

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Nakajima, M, Takahashi, A, Kou, I, Rodriguez-Fontenla, C, Gomez-Reino, JJ, Furuichi, T, Dai, J, Sudo, A, Uchida, A, Fukui, N, Kubo, M, Kamatani, N, Tsunoda, T, Malizos, KN, Tsezou, A, Gonzalez, A, Nakamura, Y & Ikegawa, S 2010, 'New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study', PloS one, vol. 5, no. 3, e9723. https://doi.org/10.1371/journal.pone.0009723

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AU - Nakajima, Masahiro

AU - Takahashi, Atsushi

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AU - Rodriguez-Fontenla, Cristina

AU - Gomez-Reino, Juan J.

AU - Furuichi, Tatsuya

AU - Dai, Jin

AU - Sudo, Akihiro

AU - Uchida, Atsumasa

AU - Fukui, Naoshi

AU - Kubo, Michiaki

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Malizos, Konstantinos N.

AU - Tsezou, Aspasia

AU - Gonzalez, Antonio

AU - Nakamura, Yusuke

AU - Ikegawa, Shiro

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AB - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

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