New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima, Atsushi Takahashi, Ikuyo Kou, Cristina Rodriguez-Fontenla, Juan J. Gomez-Reino, Tatsuya Furuichi, Jin Dai, Akihiro Sudo, Atsumasa Uchida, Naoshi Fukui, Michiaki Kubo, Naoyuki Kamatani, Tatsuhiko Tsunoda, Konstantinos N. Malizos, Aspasia Tsezou, Antonio Gonzalez, Yusuke Nakamura, Shiro Ikegawa

研究成果: Article

70 引用 (Scopus)

抄録

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

元の言語English
記事番号e9723
ジャーナルPLoS One
5
発行部数3
DOI
出版物ステータスPublished - 01-12-2010
外部発表Yes

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Knee Osteoarthritis
Genome-Wide Association Study
osteoarthritis
knees
Osteoarthritis
Genes
Single Nucleotide Polymorphism
Polymorphism
single nucleotide polymorphism
MHC Class II Genes
Nucleotides
Genome
etiology
genes
genome
genome-wide association study

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

これを引用

Nakajima, M., Takahashi, A., Kou, I., Rodriguez-Fontenla, C., Gomez-Reino, J. J., Furuichi, T., ... Ikegawa, S. (2010). New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. PLoS One, 5(3), [e9723]. https://doi.org/10.1371/journal.pone.0009723
Nakajima, Masahiro ; Takahashi, Atsushi ; Kou, Ikuyo ; Rodriguez-Fontenla, Cristina ; Gomez-Reino, Juan J. ; Furuichi, Tatsuya ; Dai, Jin ; Sudo, Akihiro ; Uchida, Atsumasa ; Fukui, Naoshi ; Kubo, Michiaki ; Kamatani, Naoyuki ; Tsunoda, Tatsuhiko ; Malizos, Konstantinos N. ; Tsezou, Aspasia ; Gonzalez, Antonio ; Nakamura, Yusuke ; Ikegawa, Shiro. / New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. :: PLoS One. 2010 ; 巻 5, 番号 3.
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abstract = "Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.",
author = "Masahiro Nakajima and Atsushi Takahashi and Ikuyo Kou and Cristina Rodriguez-Fontenla and Gomez-Reino, {Juan J.} and Tatsuya Furuichi and Jin Dai and Akihiro Sudo and Atsumasa Uchida and Naoshi Fukui and Michiaki Kubo and Naoyuki Kamatani and Tatsuhiko Tsunoda and Malizos, {Konstantinos N.} and Aspasia Tsezou and Antonio Gonzalez and Yusuke Nakamura and Shiro Ikegawa",
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Nakajima, M, Takahashi, A, Kou, I, Rodriguez-Fontenla, C, Gomez-Reino, JJ, Furuichi, T, Dai, J, Sudo, A, Uchida, A, Fukui, N, Kubo, M, Kamatani, N, Tsunoda, T, Malizos, KN, Tsezou, A, Gonzalez, A, Nakamura, Y & Ikegawa, S 2010, 'New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study', PLoS One, 巻. 5, 番号 3, e9723. https://doi.org/10.1371/journal.pone.0009723

New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. / Nakajima, Masahiro; Takahashi, Atsushi; Kou, Ikuyo; Rodriguez-Fontenla, Cristina; Gomez-Reino, Juan J.; Furuichi, Tatsuya; Dai, Jin; Sudo, Akihiro; Uchida, Atsumasa; Fukui, Naoshi; Kubo, Michiaki; Kamatani, Naoyuki; Tsunoda, Tatsuhiko; Malizos, Konstantinos N.; Tsezou, Aspasia; Gonzalez, Antonio; Nakamura, Yusuke; Ikegawa, Shiro.

:: PLoS One, 巻 5, 番号 3, e9723, 01.12.2010.

研究成果: Article

TY - JOUR

T1 - New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

AU - Nakajima, Masahiro

AU - Takahashi, Atsushi

AU - Kou, Ikuyo

AU - Rodriguez-Fontenla, Cristina

AU - Gomez-Reino, Juan J.

AU - Furuichi, Tatsuya

AU - Dai, Jin

AU - Sudo, Akihiro

AU - Uchida, Atsumasa

AU - Fukui, Naoshi

AU - Kubo, Michiaki

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Malizos, Konstantinos N.

AU - Tsezou, Aspasia

AU - Gonzalez, Antonio

AU - Nakamura, Yusuke

AU - Ikegawa, Shiro

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

AB - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

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