New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima, Atsushi Takahashi, Ikuyo Kou, Cristina Rodriguez-Fontenla, Juan J. Gomez-Reino, Tatsuya Furuichi, Jin Dai, Akihiro Sudo, Atsumasa Uchida, Naoshi Fukui, Michiaki Kubo, Naoyuki Kamatani, Tatsuhiko Tsunoda, Konstantinos N. Malizos, Aspasia Tsezou, Antonio Gonzalez, Yusuke Nakamura, Shiro Ikegawa

研究成果: Article

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Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

元の言語English
記事番号e9723
ジャーナルPloS one
5
発行部数3
DOI
出版物ステータスPublished - 01-12-2010

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Nakajima, M., Takahashi, A., Kou, I., Rodriguez-Fontenla, C., Gomez-Reino, J. J., Furuichi, T., Dai, J., Sudo, A., Uchida, A., Fukui, N., Kubo, M., Kamatani, N., Tsunoda, T., Malizos, K. N., Tsezou, A., Gonzalez, A., Nakamura, Y., & Ikegawa, S. (2010). New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. PloS one, 5(3), [e9723]. https://doi.org/10.1371/journal.pone.0009723