No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence

A. Morio, Hiroshi Ujike, A. Nomura, Y. Tanaka, Y. Morita, K. Otani, M. Kishimoto, M. Harano, T. Inada, T. Komiyama, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

研究成果: Conference contribution

7 被引用数 (Scopus)

抄録

Cocaine- and amphetamine-regulated transcript (CART) was originally discovered as a peptide that increased in the rat striatum after injection of a psychostimulant drug, such as cocaine or amphetamine, and is suggested to play potential roles in drug dependence. We tested the genetic association between the CART gene and methamphetamine (METH) dependence and/or psychosis. The subjects were 203 patients with METH dependence and 239 age- and gender-matched healthy controls. Two single nucleotide polymorphisms (SNPs) of the CART gene, -156A>G and IVS1 + 224G>A, were examined. There were no significant differences in genotype and allele distributions of the polymorphisms between patients with METH dependence and/or psychosis and controls. Neither were significant differences in subgroups of clinical phenotypes, for example, age at first consumption of METH, latency to onset of psychotic symptoms after the first consumption of METH, prognosis of psychosis after therapy, complication of spontaneous relapse to a psychotic state, or multisubstance abuse status, observed. The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population.

本文言語English
ホスト出版物のタイトルCellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity
ホスト出版物のサブタイトルCocaine, GHB, and Substituted Amphetamines
出版社Blackwell Publishing Inc.
ページ411-417
ページ数7
ISBN(印刷版)1573316296, 9781573316293
DOI
出版ステータスPublished - 08-2006

出版物シリーズ

名前Annals of the New York Academy of Sciences
1074
ISSN(印刷版)0077-8923
ISSN(電子版)1749-6632

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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