No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence

A. Morio, Hiroshi Ujike, A. Nomura, Y. Tanaka, Y. Morita, K. Otani, M. Kishimoto, M. Harano, T. Inada, T. Komiyama, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

研究成果: Conference contribution

7 引用 (Scopus)


Cocaine- and amphetamine-regulated transcript (CART) was originally discovered as a peptide that increased in the rat striatum after injection of a psychostimulant drug, such as cocaine or amphetamine, and is suggested to play potential roles in drug dependence. We tested the genetic association between the CART gene and methamphetamine (METH) dependence and/or psychosis. The subjects were 203 patients with METH dependence and 239 age- and gender-matched healthy controls. Two single nucleotide polymorphisms (SNPs) of the CART gene, -156A>G and IVS1 + 224G>A, were examined. There were no significant differences in genotype and allele distributions of the polymorphisms between patients with METH dependence and/or psychosis and controls. Neither were significant differences in subgroups of clinical phenotypes, for example, age at first consumption of METH, latency to onset of psychotic symptoms after the first consumption of METH, prognosis of psychosis after therapy, complication of spontaneous relapse to a psychotic state, or multisubstance abuse status, observed. The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population.

ホスト出版物のタイトルCellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity
ホスト出版物のサブタイトルCocaine, GHB, and Substituted Amphetamines
出版者Blackwell Publishing Inc.
ISBN(印刷物)1573316296, 9781573316293
出版物ステータスPublished - 08-2006


名前Annals of the New York Academy of Sciences


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


Morio, A., Ujike, H., Nomura, A., Tanaka, Y., Morita, Y., Otani, K., Kishimoto, M., Harano, M., Inada, T., Komiyama, T., Yamada, M., Sekine, Y., Iwata, N., Iyo, M., Sora, I., Ozaki, N., & Kuroda, S. (2006). No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence. : Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines (pp. 411-417). (Annals of the New York Academy of Sciences; 巻数 1074). Blackwell Publishing Inc..